Invention Grant
- Patent Title: Pegylated albumin and uses thereof
- Patent Title (中): 聚乙二醇化白蛋白及其用途
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Application No.: US11921064Application Date: 2006-06-09
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Publication No.: US08741832B2Publication Date: 2014-06-03
- Inventor: Seetharama A. Acharya , Belur N. Manjula
- Applicant: Seetharama A. Acharya , Belur N. Manjula
- Applicant Address: US NY Bronx
- Assignee: Albert Einstein College of Medicine of Yeshiva University
- Current Assignee: Albert Einstein College of Medicine of Yeshiva University
- Current Assignee Address: US NY Bronx
- Agency: Amster, Rothstein & Ebenstein LLP
- International Application: PCT/US2006/022463 WO 20060609
- International Announcement: WO2006/135740 WO 20061221
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K1/00 ; C07K14/00 ; C07K16/00 ; C07K17/00 ; C07K14/76 ; C07K14/805
Abstract:
The present invention provides PEGylated hemoglobins and PEGylated albumins comprising polyethylene glycol (PEG) conjugated to hemoglobin or to albumin, wherein the PEG is a maleimide PEG, an alkylamide PEG, an iodoacetamide PEG, a p-nitro thio-phenyl PEG, a vinyl sulfone PEG, or a mixed disulfide PEG; and PEGylated albumins and PEGylated hemoglobins comprising polyethylene glycol (PEG) attached to a thiolated amino group of albumin or hemoglobin, wherein the amino group is thiolated using dithio sulfo succinimidyl propionate (DTSSP) or dithiosuccinimidyl propionate (DTSP) or dithiobispropionimidate. The invention also provides methods of preparing PEGylated hemoglobins and PEGylated albumins comprising a) reacting hemoglobin or albumin with a thiolating agent and with a PEGylating agent, and b) capping unPEGylated reactive thiols of hemoglobin or albumin with N-ethyl maleimide.
Public/Granted literature
- US20090298746A1 Pegylated hemoglobin and albumin and uses thereof Public/Granted day:2009-12-03
Information query
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