Invention Grant
- Patent Title: Compounds modulators of VEGF activity and uses thereof
- Patent Title (中): VEGF活性的化合物调节剂及其用途
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Application No.: US13386506Application Date: 2010-07-23
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Publication No.: US08741850B2Publication Date: 2014-06-03
- Inventor: Luca Domenico D'Andrea , Carlo Pedone , Maria Caterina Turco
- Applicant: Luca Domenico D'Andrea , Carlo Pedone , Maria Caterina Turco
- Applicant Address: FR St. Genis Pouilly
- Assignee: Advanced Accelerator Applications S.A.
- Current Assignee: Advanced Accelerator Applications S.A.
- Current Assignee Address: FR St. Genis Pouilly
- Agency: Snell & Wilmer LLP
- International Application: PCT/EP2010/060722 WO 20100723
- International Announcement: WO2011/009944 WO 20110127
- Main IPC: A61K38/08
- IPC: A61K38/08 ; A61K38/10 ; A61K38/04 ; C07K5/00 ; C07K7/00 ; C07K16/00 ; C07K17/00 ; A61K38/16
Abstract:
Compounds of general formula (1): X1Y1X2Y2X3Y3X4Y4Y5X5X6Y6X7Y7X8X9X10 wherein X1-X10 are any natural or unnatural amino acids and Y1 is Gln; Y2 is Met or Leu; Y3 is He; Y4 is Pro or Ser; Y5 is His or Gly; Y6 is Gln or Pro; Y7 is He or Tyr or their homolog or ortolog are described; these compounds are able to bind to the VEGF receptors and to modulate the angiogenesis mediated by the VEG.
Public/Granted literature
- US20120114565A1 COMPOUNDS MODULATORS OF VEGF ACTIVITY AND USES THEREOF Public/Granted day:2012-05-10
Information query
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