Invention Grant
US08741922B2 Solid forms of N-(4-(7-azabicyclo[2.2,1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide
有权
固体形式的N-（4-（7-氮杂双环[2.2,1]庚-7-基）-2-三氟甲基）苯基）-4-氧代-5-（三氟甲基）-1,4-二氢喹啉-3-甲酰胺
![Solid forms of N-(4-(7-azabicyclo[2.2,1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide](/docs/US/2014-06-03/US08741922B2/abs.jpg.600x600.jpg)
- Patent Title: Solid forms of N-(4-(7-azabicyclo[2.2,1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide
- Patent Title (中): 固体形式的N-（4-（7-氮杂双环[2.2,1]庚-7-基）-2-三氟甲基）苯基）-4-氧代-5-（三氟甲基）-1,4-二氢喹啉-3-甲酰胺
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Application No.: US13751656Application Date: 2013-01-28
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Publication No.: US08741922B2Publication Date: 2014-06-03
- Inventor: Beili Zhang , Mariusz Krawiec , Brian Luisi , Ales Medek
- Applicant: Vertex Pharmaceuticals Incorporated
- Applicant Address: US MA Boston
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Boston
- Agency: Honigman Miller Schwartz and Cohn LLP
- Agent Christopher C. Forbes; Jonathan P. O'Brien
- Main IPC: A61K31/04
- IPC: A61K31/04 ; A61K31/4748
![Solid forms of N-(4-(7-azabicyclo[2.2,1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide](/abs-image/US/2014/06/03/US08741922B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to substantially crystalline and solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide (Form A-HCl, Form B, Form B-HCl, or any combination of these forms), pharmaceutical compositions thereof, and methods of treatment therewith.
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