Invention Grant
- Patent Title: Method of modulating stress-activated protein kinase system
- Patent Title (中): 调节应激激活蛋白激酶系统的方法
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Application No.: US13528624Application Date: 2012-06-20
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Publication No.: US08741936B2Publication Date: 2014-06-03
- Inventor: Lawrence M. Blatt , Scott D. Seiwert , Leonid Beigelman , Ramachandran Radhakrishnan , Karl Kossen , Vladimir Serebryany
- Applicant: Lawrence M. Blatt , Scott D. Seiwert , Leonid Beigelman , Ramachandran Radhakrishnan , Karl Kossen , Vladimir Serebryany
- Applicant Address: US CA Brisbane
- Assignee: Intermune, Inc.
- Current Assignee: Intermune, Inc.
- Current Assignee Address: US CA Brisbane
- Agency: Knobbe Martens Olson & Bear LLP
- Main IPC: A01N43/40
- IPC: A01N43/40 ; A61K31/44 ; C07D213/62 ; C07D213/78 ; C07D211/72 ; C07D211/84 ; C07D213/63 ; C07D213/70 ; A61K31/45 ; C07D213/16 ; C07D213/64
Abstract:
Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the at least one p38 MAPK by the compound. Also disclosed are derivatives of pirfenidone. These derivatives can modulate a stress activated protein kinase (SAPK) system.
Public/Granted literature
- US20120258924A1 METHOD OF MODULATING STRESS-ACTIVATED PROTEIN KINASE SYSTEM Public/Granted day:2012-10-11
Information query
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