Invention Grant
US08741982B2 Bioactive bone cement and method for the production thereof 有权
生物活性骨水泥及其生产方法

  • Patent Title: Bioactive bone cement and method for the production thereof
  • Patent Title (中): 生物活性骨水泥及其生产方法
  • Application No.: US11914382
    Application Date: 2006-05-09
  • Publication No.: US08741982B2
    Publication Date: 2014-06-03
  • Inventor: Berthold Nies
  • Applicant: Berthold Nies
  • Applicant Address: DE Radebeul
  • Assignee: InnoTERE GmbH
  • Current Assignee: InnoTERE GmbH
  • Current Assignee Address: DE Radebeul
  • Agent Gudrun E. Huckett
  • Priority: DE102005023094 20050513
  • International Application: PCT/EP2006/004330 WO 20060509
  • International Announcement: WO2006/122678 WO 20061123
  • Main IPC: A61L24/06
  • IPC: A61L24/06 A61K6/083 A61K6/08 A61F2/28 A61K9/14 C08L33/12 C08L31/02
Bioactive bone cement and method for the production thereof
Abstract:
A bioactive and osteoconductive bone cement is produced from polyacrylates or polymethylacrylates by addition of small amounts of polymerizable monomers containing anionic groups which cause the cement surface to mineralize after being incubated in simulated body fluid. The obtained mineralized layers contain calcium phosphate phases such that the formation of fibrous intermediate layers is prevented once the bone cement has been implanted in bones. Optionally, other additives, e.g. biocompatible calcium salts, biocompatible buffering substances, or x-ray contrast agents, antibiotics, antimicrobial agents, and/or anti-inflammatory agents can be added in order to improve the properties of the cement for individual purposes. The bone cement can be used for anchoring prosthesis components in the bone, stiffening bones, filling and reconstructing all types of bone defects, as dowels for bone screws, or as an implant material for anchoring screws and other implants used for osteosynthesis.
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