Invention Grant
US08742076B2 Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
有权
Nemorubicin代谢物和类似物，抗体 - 药物共轭物和方法
- Patent Title: Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
- Patent Title (中): Nemorubicin代谢物和类似物，抗体 - 药物共轭物和方法
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Application No.: US12865354Application Date: 2009-01-16
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Publication No.: US08742076B2Publication Date: 2014-06-03
- Inventor: Robert L. Cohen , Edward HyungSuk Ha , Mark E. Reynolds
- Applicant: Robert L. Cohen , Edward HyungSuk Ha , Mark E. Reynolds
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Genentech, Inc.
- Agent Alex Andrus
- International Application: PCT/US2009/031199 WO 20090116
- International Announcement: WO2009/099741 WO 20090813
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C07K14/00 ; A61K39/00
Abstract:
The present invention relates to antibody-drug conjugate compounds of Formula I: Ab-(L-D)p I where one or more nemorubicin metabolite or analog drug moieties (D) are covalently attached by a linker (L) to an antibody (Ab) which binds to one or more tumor-associated antigens or cell-surface receptors. These compounds may be useful in methods of diagnosis or treatment of cancer, and other diseases and disorders.
Public/Granted literature
- US20110076287A1 NEMORUBICIN METABOLITE AND ANALOG REAGENTS, ANTIBODY-DRUG CONJUGATES AND METHODS Public/Granted day:2011-03-31
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