Invention Grant
US08742088B2 Nucleic acids encoding antibodies or portions thereof comprising a heterologous T cell epitope and their use in modulating T cell responses
有权
编码抗体或其部分的核酸包含异源T细胞表位及其在调节T细胞应答中的用途
- Patent Title: Nucleic acids encoding antibodies or portions thereof comprising a heterologous T cell epitope and their use in modulating T cell responses
- Patent Title (中): 编码抗体或其部分的核酸包含异源T细胞表位及其在调节T细胞应答中的用途
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Application No.: US12566465Application Date: 2009-09-24
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Publication No.: US08742088B2Publication Date: 2014-06-03
- Inventor: Linda Gillian Durrant , Rachael Louise Metheringham , Victoria Anne Pudney
- Applicant: Linda Gillian Durrant , Rachael Louise Metheringham , Victoria Anne Pudney
- Applicant Address: GB Nottingham
- Assignee: Scancell Limited
- Current Assignee: Scancell Limited
- Current Assignee Address: GB Nottingham
- Agency: Elmore Patent Law Group, P.C.
- Agent Darlene A. Vanstone, Esq.; Carolyn S. Elmore, Esq.
- Priority: GB0706070.0 20070328
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C07K19/00
Abstract:
The present invention provides a nucleic acid which comprises a non-specific promoter and at least one sequence that encodes a polypeptide that has at least one heterologous T cell epitope therein but does not have any regulatory T cell epitopes. The polypeptide may be one chain of a heterodimer such as the heavy or light chain of an antibody molecule, the heterologous T cell epitope causing disruption of the heterodimer chain such that it cannot bind with the other chain of the heterodimer. The nucleic acid can be used to raise a T cell response against the at least one heterologous T cell epitope.
Public/Granted literature
- US20100260806A1 NUCLEIC ACIDS Public/Granted day:2010-10-14
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