Invention Grant
- Patent Title: Method for the solid phase-based production of phosphate-bridged nucleoside conjugates
- Patent Title (中): 磷酸桥连核苷轭合物的固相制备方法
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Application No.: US13319108Application Date: 2010-05-06
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Publication No.: US08742094B2Publication Date: 2014-06-03
- Inventor: Chris Meier , Viktoria Caroline Tonn
- Applicant: Chris Meier , Viktoria Caroline Tonn
- Applicant Address: DE Hamburg
- Assignee: Universitaet Hamburg
- Current Assignee: Universitaet Hamburg
- Current Assignee Address: DE Hamburg
- Agency: Patent Central LLC
- Agent Stephan A. Pendorf
- Priority: DE102009020261 20090507
- International Application: PCT/DE2010/000508 WO 20100506
- International Announcement: WO2010/127666 WO 20101111
- Main IPC: C07H19/04
- IPC: C07H19/04 ; C07H19/20 ; C07G3/00 ; C07H17/00 ; C08B37/00 ; C07H5/04 ; C07H5/06
Abstract:
The invention relates to a method for producing phosphate-bridged nucleoside conjugates. In the method, a cyclosaligenyl nucleotide is produced first, to which a linker is added, which is used to perform the immobilization on a solid phase. A subsequent reaction with corresponding nucleophiles results in the desired phosphate-bridged nucleoside conjugates, which can then again be cleaved from the solid phase-bound linker.
Public/Granted literature
- US20120116067A1 METHOD FOR THE SOLID PHASE-BASED PRODUCTION OF PHOSPHATE-BRIDGED NUCLEOSIDE CONJUGATES Public/Granted day:2012-05-10
Information query
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