Invention Grant
- Patent Title: Inhibitors of Bruton's tyrosine kinase
- Patent Title (中): Bruton酪氨酸激酶抑制剂
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Application No.: US13706399Application Date: 2012-12-06
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Publication No.: US08742098B2Publication Date: 2014-06-03
- Inventor: Christine E. Brotherton-Pleiss , Francisco Javier Lopez-Tapia , Yan Lou
- Applicant: Hoffmann-La Roche Inc.
- Applicant Address: US NJ Nutley
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Main IPC: C07D413/14
- IPC: C07D413/14 ; A61K31/5377

Abstract:
This application discloses compounds according to generic Formula I: wherein the variables are defined as described herein, and which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation, such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
Public/Granted literature
- US20130150360A1 INHIBITORS OF BRUTON'S TYROSINE KINASE Public/Granted day:2013-06-13
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