Invention Grant
US08742100B2 Small molecule inhibitors of isoprenylcysteine carboxyl methyltransferase with potential anticancer activity
失效
具有潜在抗癌活性的异戊烯基半胱氨酸羧甲基转移酶的小分子抑制剂
- Patent Title: Small molecule inhibitors of isoprenylcysteine carboxyl methyltransferase with potential anticancer activity
- Patent Title (中): 具有潜在抗癌活性的异戊烯基半胱氨酸羧甲基转移酶的小分子抑制剂
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Application No.: US13388050Application Date: 2010-07-30
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Publication No.: US08742100B2Publication Date: 2014-06-03
- Inventor: Jo Lene Leow , Mei-Wang Casey , Patrick J. Casey , Mei Lin Go , Kumar Gorla Suresh
- Applicant: Jo Lene Leow , Mei-Wang Casey , Patrick J. Casey , Mei Lin Go , Kumar Gorla Suresh
- Applicant Address: SG Singapore
- Assignee: National University of Singapore
- Current Assignee: National University of Singapore
- Current Assignee Address: SG Singapore
- Agency: Blakely, Sokoloff, Taylor & Zafman LLP
- Priority: SG200905128 20090730; SG200907728 20091120
- International Application: PCT/SG2010/000286 WO 20100730
- International Announcement: WO2011/014128 WO 20110203
- Main IPC: C07D209/14
- IPC: C07D209/14 ; C07D401/06 ; C07D403/06 ; C07D413/06
Abstract:
The present invention generally relates to inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt), in particularly to compounds that inhibit Icmt activity and pharmaceutical compositions thereof. The invention also relates to methods of disease treatment using the same.
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