Invention Grant
- Patent Title: HIV integrase inhibitors from pyridoxine
- Patent Title (中): 来自吡哆醇的HIV整合酶抑制剂
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Application No.: US12995890Application Date: 2009-06-04
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Publication No.: US08742123B2Publication Date: 2014-06-03
- Inventor: Brent Stranix , Francis Beaulieu , Jean-Emmanuel Bouchard , Guy Milot , Wang Zhigang , Réjean Ruel
- Applicant: Brent Stranix , Francis Beaulieu , Jean-Emmanuel Bouchard , Guy Milot , Wang Zhigang , Réjean Ruel
- Applicant Address: TW Taipei
- Assignee: TaiMed Biologics, Inc.
- Current Assignee: TaiMed Biologics, Inc.
- Current Assignee Address: TW Taipei
- Agency: Clark & Elbing LLP
- International Application: PCT/CA2009/000787 WO 20090604
- International Announcement: WO2009/146555 WO 20091210
- Main IPC: A61K31/44
- IPC: A61K31/44 ; C07D213/81
Abstract:
The present invention relates to pyridoxine (vitamin B6) derived compounds of formula (I), pharmaceutically acceptable salts, or solvates thereof, wherein R1, R2, R4, A, L B1 and B2 are as defined in the specification, and pharmaceutical compositions comprising the compounds. Compounds of formula (I) inhibit Human Immunodeficiency Virus (HIV)-integrase enzyme and are useful for preventing and treating HIV infection and AIDS.
Public/Granted literature
- US20110178120A1 HIV INTEGRASE INHIBITORS FROM PYRIDOXINE Public/Granted day:2011-07-21
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