Invention Grant
US08742161B2 Process for producing optically active bicyclo [3.1.0] hexane derivative using enzyme
有权
使用酶制备光学双环[3.1.0]己烷衍生物的方法
![Process for producing optically active bicyclo [3.1.0] hexane derivative using enzyme](/docs/US/2014-06-03/US08742161B2/abs.jpg.600x600.jpg)
- Patent Title: Process for producing optically active bicyclo [3.1.0] hexane derivative using enzyme
- Patent Title (中): 使用酶制备光学双环[3.1.0]己烷衍生物的方法
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Application No.: US13510375Application Date: 2010-11-18
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Publication No.: US08742161B2Publication Date: 2014-06-03
- Inventor: Joji Sasaki
- Applicant: Joji Sasaki
- Applicant Address: JP Tokyo
- Assignee: Taisho Pharmaceutical Co., Ltd
- Current Assignee: Taisho Pharmaceutical Co., Ltd
- Current Assignee Address: JP Tokyo
- Agency: Sughrue Mion, PLLC
- Priority: JP2009-262827 20091118
- International Application: PCT/JP2010/006756 WO 20101118
- International Announcement: WO2011/061934 WO 20110526
- Main IPC: C07C69/74
- IPC: C07C69/74 ; C12P7/38
![Process for producing optically active bicyclo [3.1.0] hexane derivative using enzyme](/abs-image/US/2014/06/03/US08742161B2/abs.jpg.150x150.jpg)
Abstract:
There is provided a process for producing a bicyclo [3.1.0] hexane derivative represented by the formula (I) and a salt thereof including; causing an enzyme to act on an optically inactive compound represented by the formula (II) causing an asymmetric acylation reaction and a highly-stereoselective conversion to an optically active compound represented by the formula (III); and converting the compound represented by the formula (III) to the compound represented by the formula (I) or a salt thereof.
Public/Granted literature
- US20120232304A1 PROCESS FOR PRODUCING OPTICALLY ACTIVE BICYCLO [3.1.0] HEXANE DERIVATIVE USING ENZYME Public/Granted day:2012-09-13
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