Invention Grant
- Patent Title: Phenolic hydrazone macrophage migration inhibitory factor inhibitors
- Patent Title (中): 酚腙巨噬细胞迁移抑制因子抑制剂
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Application No.: US13418877Application Date: 2012-03-13
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Publication No.: US08742173B2Publication Date: 2014-06-03
- Inventor: Yousef Al-Abed
- Applicant: Yousef Al-Abed
- Applicant Address: US NY Manhasset
- Assignee: The Feinstein Institute for Medical Research
- Current Assignee: The Feinstein Institute for Medical Research
- Current Assignee Address: US NY Manhasset
- Agency: Amster, Rothstein & Ebenstein LLP
- Main IPC: C07C251/86
- IPC: C07C251/86
Abstract:
Provided are various compounds of Formula (I): Also provided are pharmaceutical compositions comprising the above compounds. Additionally, methods of inhibiting macrophage migration inhibitory factor (MIF) activity in a mammal are provided, as are methods of treating or preventing inflammation in a mammal. Further provided are methods of treating a mammal having sepsis, septicemia, and/or endotoxic shock. Also provided are methods of treating a mammal having an autoimmune disease, and methods of treating a mammal having a tumor.
Public/Granted literature
- US20120178805A1 PHENOLIC HYDRAZONE MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS Public/Granted day:2012-07-12
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