The present disclosure provides a method and system for remote control of a smart card. The method comprises that: a smart card management platform receives a request of locking or unlocking a smart card from a subscriber; and the smart card management platform performs interactive processing with a terminal side according to the request via a mobile network platform, so as to enable the terminal side to perform the locking or unlocking of the smart card. The present disclosure enables the payment subscriber to avoid loss when the terminal is robbed, lost, stolen, or is illegally used seriously, and provide a higher flexibility to the payment system.