A hybrid computational fluid dynamics (CFD) approach for modeling a bounded domain, such as a data center, is disclosed. The CFD modeling approach divides the bounded domain into one or more viscous regions and one or more inviscid regions, and then performs a viscous domain solve for the viscous region(s) using a computational fluid dynamics model with turbulence equations (i.e., a turbulence model), and performs inviscid domain solve for the inviscid region(s) using a set of inviscid equations (or potential flow equations). After solving for the different regions, results of the viscous domain solve and the inviscid domain solve are provided as a model of the bounded domain.