A method of simulating the behavior of an articulated set of bone parts, in particular the vertebral column comprising a construction step of constructing a three-dimensional geometrical model from data that is specific to the subject in a reference position; and a mechanical customization step of determining the geometrical model by detailing at least some of the connection areas of the bone parts. The mechanical customization step includes a stage of customizing critical connection areas for the bone parts; a data acquisition stage of acquiring data concerning the articulated bone set of the subject during at least one clinical test of posture; and a characterization stage for characterizing the mechanical parameters of said junction areas in order to cause the model to reproduce the data acquired during the above-mentioned clinical test.