The invention relates to systems and methods of global load balancing in a content delivery network having a plurality of edge servers which may be distributed across multiple geographic locations. According to one aspect of the invention, a global load balancing system includes a first load balancing server for receiving a packet requesting content to be delivered to a client, selecting one of the plurality of edge servers to deliver the requested content to the client, and forwarding the packet across a network connection to a second load balancing server, which forwards the packet to the selected edge server. The selected edge server, in response to receiving the packet, sends across a network connection the requested content with an address for direct delivery to the client, thereby allowing the requested content to be delivered to the client while bypassing a return path through the first load balancing server.