Systems and methods for providing enhancement of upload and/or download performance based on client and/or server feedback information are disclosed. In an embodiment, the disclosed method detects that a data transfer event is about to occur and based on a set of characteristics associated with the data transfer event, selects a host from a group of hosts as a pathway for transferring data associated with the data transfer event to optimize data transfer performance. The group of hosts can include a server providing cloud-based collaboration and/or storage services, one or more content delivery network servers and/or geographically distributed edge servers.