Systems for accessing a well bore including a BOP stack with a universal intervention interface are disclosed. In some embodiments, the system includes a BOP stack and a valve assembly. The BOP stack has a throughbore and is installable on a well such that the throughbore is in fluid communication with the well bore. The valve assembly is coupled to the BOP stack and includes a fluid flowpath in fluid communication with the BOP stack throughbore, two valves connected in series and disposed along the fluid flowpath, the valves operable to control flow through the fluid flowpath, and a ROV panel including ports accessible by a ROV for operation of the two valves.