A fluid ejection apparatus includes a printhead having a substrate. The substrate includes a nozzle face having a width direction and a length direction. The nozzle face includes a set of four columns of nozzles oriented in a column direction substantially along the width direction of the nozzle face, and the nozzles in each column are positioned on a straight line along the column. A spacing between two adjacent columns of the four adjacent columns is different than a spacing between another two adjacent columns of the four adjacent columns. In some implementations, a controller can control timing of ejection of fluid droplets from the nozzles to deposit lines of fluid droplets on a medium, and the medium can travel relative to the nozzle face.