A probe manipulator which has a grip device that can be held by a user in order to facilitate manipulation of a probe when the latter has been inserted into a channel of an endoscope. Connection devices are provided for releasably connecting the grip device to the probe in such a way that the probe may be rotated or displaced by rotation or displacement of the grip device. The connection device is connectable such that the probe need not be fed through the grip device, but that the grip device may be placed at any point along the length of the probe.