A system and method for managing respiratory insufficiency through remote patient care is described. A patient enrolled in remote patient care is identified with information including at least one of treatment profile and medical history. Collected device measures are received to record raw physiometry for a patient, wherein the patient is regularly monitored by a medical device. Derived device measures are generated to provide derivative physiometry based on the collected device measures. A patient status indicator is determined by analyzing the collected and derived device measures to diagnose a pathophysiology indicative of respiratory insufficiency.