Invention Grant
US08747809B2 Single diastereomers of 4-fluoroglutamine and methods of their preparation and use
有权
4-氟谷氨酰胺的单一非对映异构体及其制备和使用方法
- Patent Title: Single diastereomers of 4-fluoroglutamine and methods of their preparation and use
- Patent Title (中): 4-氟谷氨酰胺的单一非对映异构体及其制备和使用方法
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Application No.: US13389521Application Date: 2010-08-13
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Publication No.: US08747809B2Publication Date: 2014-06-10
- Inventor: Hank F. Kung , Craig B. Thompson , Wenchao Qu , Karl Ploessl
- Applicant: Hank F. Kung , Craig B. Thompson , Wenchao Qu , Karl Ploessl
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees Of The University Of Pennsylvania
- Current Assignee: The Trustees Of The University Of Pennsylvania
- Current Assignee Address: US PA Philadelphia
- Agency: Baker & Hostetler LLP
- International Application: PCT/US2010/045470 WO 20100813
- International Announcement: WO2011/020018 WO 20110217
- Main IPC: A61K51/00
- IPC: A61K51/00 ; C07D209/48
Abstract:
The present invention is directed single diasteromers of 4-fluoroglutamine having a diastereomeric excess of at least 80%. Methods of preparing the single diastereomers are also described, as well as methods of using the single diastereomers of radiolabeled 4-fluoroglutamine as imaging agent is also described.
Public/Granted literature
- US20120288444A1 SINGLE DIASTEREOMERS OF 4-FLUOROGLUTAMINE AND METHODS OF THEIR PREPARATION AND USE Public/Granted day:2012-11-15
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