Invention Grant
US08747866B2 Identification of virulence associated regions RD1 and RD5 leading to improve vaccine of M. bovis BCG and M. microti
失效
鉴定毒力相关区域RD1和RD5，导致改进牛分枝杆菌BCG和M. microti的疫苗
- Patent Title: Identification of virulence associated regions RD1 and RD5 leading to improve vaccine of M. bovis BCG and M. microti
- Patent Title (中): 鉴定毒力相关区域RD1和RD5，导致改进牛分枝杆菌BCG和M. microti的疫苗
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Application No.: US12923432Application Date: 2010-09-21
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Publication No.: US08747866B2Publication Date: 2014-06-10
- Inventor: Stewart Cole , Alexander S. Pym , Roland Brosch , Priscille Brodin , Laleh Majlessi , Caroline Demangel , Claude LeClerc
- Applicant: Stewart Cole , Alexander S. Pym , Roland Brosch , Priscille Brodin , Laleh Majlessi , Caroline Demangel , Claude LeClerc
- Applicant Address: FR Paris
- Assignee: Institut Pasteur
- Current Assignee: Institut Pasteur
- Current Assignee Address: FR Paris
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- Main IPC: A61K39/04
- IPC: A61K39/04 ; C07H21/02 ; C07H21/04
Abstract:
The present invention relates to a strain of M. bovis BCG or M. microti, wherein said strain has integrated part or all of the RD1 region responsible for enhanced immunogenicity of the tubercle bacilli, especially the ESAT-6 and CFP-10 genes. These strains will be referred as the M. bovis BCG::RD1 or M. microti::RD1 strains and are useful as a new improved vaccine for preventing tuberculosis and as a therapeutical product enhancing the stimulation of the immune system for the treatment of bladder cancer.
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