Invention Grant
US08748114B2 ZAP-70 expression as a marker for chronic lymphocytic leukemia / small lymphocytic lymphoma (CLL/SLL)
有权
ZAP-70表达作为慢性淋巴细胞白血病/小淋巴细胞淋巴瘤（CLL / SLL）的标记物
- Patent Title: ZAP-70 expression as a marker for chronic lymphocytic leukemia / small lymphocytic lymphoma (CLL/SLL)
- Patent Title (中): ZAP-70表达作为慢性淋巴细胞白血病/小淋巴细胞淋巴瘤（CLL / SLL）的标记物
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Application No.: US13155198Application Date: 2011-06-07
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Publication No.: US08748114B2Publication Date: 2014-06-10
- Inventor: Louis M. Staudt , Andreas Rosenwald , Wyndham Wilson , Todd S. Barry , Adrian Wiestner
- Applicant: Louis M. Staudt , Andreas Rosenwald , Wyndham Wilson , Todd S. Barry , Adrian Wiestner
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
- Current Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Klarquist Sparkman, LLP
- Main IPC: G01N33/574
- IPC: G01N33/574
Abstract:
It has been surprisingly found that ZAP-70 expression, both at the protein and mRNA levels, is indicative of clinical subgroups of CLL/SLL patients. In particular, high ZAP-70 expression is indicative of Ig-unmutated CLL/SLL. Methods are provided for discriminating between clinical subgroups of CLL/SLL, by determining whether subjects overexpress ZAP-70 mRNA or protein.
Public/Granted literature
- US20110236915A1 ZAP-70 EXPRESSION AS A MARKER FOR CHRONIC LYMPHOCYTIC LEUKEMIA / SMALL LYMPHOCYTIC LYMPHOMA (CLL/SLL) Public/Granted day:2011-09-29
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