Invention Grant
- Patent Title: Process for preparing inclusion body-forming protein
- Patent Title (中): 制备包涵体形成蛋白的方法
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Application No.: US13125328Application Date: 2009-10-21
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Publication No.: US08748132B2Publication Date: 2014-06-10
- Inventor: Hiroshi Nakatake , Akihiro Meta , Kiyotaka Suenaga , Masaki Hirashima , Hiroaki Maeda
- Applicant: Hiroshi Nakatake , Akihiro Meta , Kiyotaka Suenaga , Masaki Hirashima , Hiroaki Maeda
- Applicant Address: JP Kumamoto-shi JP Tokyo-to
- Assignee: The Chemo-Sero-Therapeutic Research Institute,Teijin Pharma Limited
- Current Assignee: The Chemo-Sero-Therapeutic Research Institute,Teijin Pharma Limited
- Current Assignee Address: JP Kumamoto-shi JP Tokyo-to
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2008-270941 20081021
- International Application: PCT/JP2009/068133 WO 20091021
- International Announcement: WO2010/047347 WO 20100429
- Main IPC: C12P21/04
- IPC: C12P21/04
Abstract:
A process for preparing an inclusion body-forming protein is provided. A nucleic acid fragment having a nucleotide sequence coding for a modified alkaline phosphatase signal peptide (modified APSP) where leucine at the 13th position in the amino acid sequence shown in SEQ ID NO: 1 is substituted with proline and/or alanine at the 21st position is substituted with the other amino acid, downstream of which nucleotide sequence is bound a nucleotide sequence of a gene of a protein of interest is also provided.
Public/Granted literature
- US20110262998A1 PROCESS FOR PREPARING INCLUSION BODY-FORMING PROTEIN Public/Granted day:2011-10-27
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