Invention Grant
US08748372B2 Polynucleotide encoding a TRIM-cyp polypeptide, compositions thereof, and methods of using same
失效
编码TRIM-cyp多肽的多核苷酸，其组合物及其使用方法
- Patent Title: Polynucleotide encoding a TRIM-cyp polypeptide, compositions thereof, and methods of using same
- Patent Title (中): 编码TRIM-cyp多肽的多核苷酸，其组合物及其使用方法
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Application No.: US13331363Application Date: 2011-12-20
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Publication No.: US08748372B2Publication Date: 2014-06-10
- Inventor: Jeremy Luban , David Sayah
- Applicant: Jeremy Luban , David Sayah
- Applicant Address: US NY New York
- Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee Address: US NY New York
- Agency: Wilmer Cutler Pickering Hale and Dorr LLP
- Main IPC: C07K19/00
- IPC: C07K19/00 ; C12N5/07 ; A61P31/18 ; A61K9/127
Abstract:
The invention provides an isolated nucleic acid encoding a TRIM-cyclophilin A fusion sequence encoding a TRIMcyp fusion protein which is active as an anti-viral agent, and in particular an anti-HIV-1 agent. The invention provides for a nucleic acid encoding a polypeptide having both TRIM activity and cyclophilin activity. The invention provides for an isolated polynucleotide encoding a TRIM-cyclophilin fusion protein, or variants thereof retaining the TRIM and cyclophilin activities. The invention provides for compositions thereof, antibodies that specifically bind thereto, and vectors and host cells comprising the nucleic acid or polypeptide. In addition, the invention provides for methods for treating or preventing viral infection, or reducing viral load in a subject comprising administering the nucleic acid, polypeptide, vector, or composition to the subject in an amount effective to treat or prevent the viral infection.
Public/Granted literature
- US20130084327A1 POLYNUCLEOTIDE ENCODING A TRIM-CYP POLYPEPTIDE, COMPOSITIONS THEREOF, AND METHODS OF USING SAME Public/Granted day:2013-04-04
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