Invention Grant
- Patent Title: Antineoplastic compounds and pharmaceutical compositions thereof
- Patent Title (中): 抗肿瘤化合物及其药物组合物
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Application No.: US11920031Application Date: 2006-05-05
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Publication No.: US08748411B2Publication Date: 2014-06-10
- Inventor: Rolando Eduardo Rodriguez Fernandez , Roberto Vera Alvarez , Ania De La Nuez Veulens , Yuliet Mazola Reyes , Silvio Ernesto Perea Rodriguez , Boris Ernesto Acevedo Castro , Alexis Musacchio Lasa , Raimundo Ubieta Gómez
- Applicant: Rolando Eduardo Rodriguez Fernandez , Roberto Vera Alvarez , Ania De La Nuez Veulens , Yuliet Mazola Reyes , Silvio Ernesto Perea Rodriguez , Boris Ernesto Acevedo Castro , Alexis Musacchio Lasa , Raimundo Ubieta Gómez
- Applicant Address: CU Ciudad de la Habana
- Assignee: Centro de Ingenieria Genetica y Biotechnologia
- Current Assignee: Centro de Ingenieria Genetica y Biotechnologia
- Current Assignee Address: CU Ciudad de la Habana
- Agency: Hoffmann & Baron, LLP
- Priority: CU2005-091 20050512
- International Application: PCT/CU2006/000002 WO 20060505
- International Announcement: WO2006/119713 WO 20061116
- Main IPC: A61K31/66
- IPC: A61K31/66 ; A61K31/53 ; A61K31/505 ; A61K31/47 ; A61K31/415 ; A61K31/40 ; C07D251/42 ; C07D473/00 ; C07D239/02 ; C07D215/38 ; C07D235/00 ; C07D233/96 ; C07D209/14 ; C07D307/02 ; C07D229/00 ; C07F9/02 ; C07C281/02 ; C07C273/02 ; C07C303/00 ; C07C241/00
Abstract:
Chemical compounds derived by in silico molecular modelling, having a well defined structure suitable for the blocking of the phosphorylation event, through the specific interaction of the chemical with the Casein Kinase 2 enzyme substrate phosphorylation domain or it's neighbourhood. This invention comprises also the pharmaceutical compositions containing such compounds, and their use in the preparation of medicines or agents for the treatment of diseases or conditions related with neoplasic processes.
Public/Granted literature
- US20090215730A1 Antineoplastic compounds and pharmaceutical compositions thereof Public/Granted day:2009-08-27
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