Invention Grant
US08748437B2 Crystal of 2-(3,4 dichlorobenzyl)-5-methyl-4-oxo-3,4-dihydrothien[2,3-D]pyrimidine-6-carboxylic acid
有权
2-（3,4-二氯苄基）-5-甲基-4-氧代-3,4-二氢噻吩并[2,3-D]嘧啶-6-甲酸
![Crystal of 2-(3,4 dichlorobenzyl)-5-methyl-4-oxo-3,4-dihydrothien[2,3-D]pyrimidine-6-carboxylic acid](/docs/US/2014-06-10/US08748437B2/abs.jpg.600x600.jpg)
- Patent Title: Crystal of 2-(3,4 dichlorobenzyl)-5-methyl-4-oxo-3,4-dihydrothien[2,3-D]pyrimidine-6-carboxylic acid
- Patent Title (中): 2-（3,4-二氯苄基）-5-甲基-4-氧代-3,4-二氢噻吩并[2,3-D]嘧啶-6-甲酸
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Application No.: US13700935Application Date: 2011-05-31
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Publication No.: US08748437B2Publication Date: 2014-06-10
- Inventor: Hiroyuki Hayashi , Takayoshi Nakagawa , Koichi Miyazaki
- Applicant: Hiroyuki Hayashi , Takayoshi Nakagawa , Koichi Miyazaki
- Applicant Address: JP Tokyo
- Assignee: ASKA Pharmaceutical Co., Ltd.
- Current Assignee: ASKA Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Leydig, Voit & Mayer, Ltd.
- Priority: JP2010-125362 20100531
- International Application: PCT/JP2011/062513 WO 20110531
- International Announcement: WO2011/152411 WO 20111208
- Main IPC: A61K31/519
- IPC: A61K31/519
![Crystal of 2-(3,4 dichlorobenzyl)-5-methyl-4-oxo-3,4-dihydrothien[2,3-D]pyrimidine-6-carboxylic acid](/abs-image/US/2014/06/10/US08748437B2/abs.jpg.150x150.jpg)
Abstract:
The invention provides a crystal of 2-(3,4-dichlorobenzyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid (which has the chemical structure shown below) and a mixed crystal comprising such a crystal. The invention also provides methods of producing such crystals, pharmaceutical compositions comprising such crystals, and methods of modulating phosphodiesterase-9 activity and treating disorders such as overactive bladder syndrome by administration of an effective amount of the crystals.
Public/Granted literature
- US20130123279A1 CRYSTAL OF THIENOPYRIMIDINE DERIVATIVE Public/Granted day:2013-05-16
Information query
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