Invention Grant
US08748449B2 Use of polyols to obtain stable polymorphous forms of rifaximin
有权
使用多元醇获得稳定的多形态形式的利福昔明
- Patent Title: Use of polyols to obtain stable polymorphous forms of rifaximin
- Patent Title (中): 使用多元醇获得稳定的多形态形式的利福昔明
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Application No.: US13544945Application Date: 2012-07-09
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Publication No.: US08748449B2Publication Date: 2014-06-10
- Inventor: Paola Maffei , Milena Bachetti , Giuseppe Bottoni , Giuseppe Claudio Viscomi
- Applicant: Paola Maffei , Milena Bachetti , Giuseppe Bottoni , Giuseppe Claudio Viscomi
- Applicant Address: IT Alanno (PE)
- Assignee: Alfa Wassermann S.p.A.
- Current Assignee: Alfa Wassermann S.p.A.
- Current Assignee Address: IT Alanno (PE)
- Agency: Steinfl & Bruno LLP
- Priority: ITMI2006A1692 20060905
- Main IPC: A61K31/44
- IPC: A61K31/44 ; A61K31/437
Abstract:
Polyols stabilize polymorphous form of rifaximin, in particular the β form. When polyols having at least two hydroxy groups are added to rifaximin powder, polymorph β is stable and remains stable in time independently from the environment humidity.In this invention a method to prepare formulations constituted by pure and stable polymorphous forms able to give a pharmaceutical product is described.
Public/Granted literature
- US20130072676A1 USE OF POLYOLS TO OBTAIN STABLE POLYMORPHOUS FORMS OF RIFAXIMIN Public/Granted day:2013-03-21
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