Invention Grant
- Patent Title: Scriptaid isosteres and their use in therapy
- Patent Title (中): 经典脚本及其在治疗中的应用
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Application No.: US13145250Application Date: 2010-01-26
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Publication No.: US08748458B2Publication Date: 2014-06-10
- Inventor: Stephen Joseph Shuttleworth , Cyrille Davy Tomassi
- Applicant: Stephen Joseph Shuttleworth , Cyrille Davy Tomassi
- Applicant Address: GB Hampshire
- Assignee: Karus Therapeutics Limited
- Current Assignee: Karus Therapeutics Limited
- Current Assignee Address: GB Hampshire
- Agency: Saliwanchik, Lloyd & Eisenschenk
- Priority: GB0901406.9 20090128; GB0912383.7 20090716
- International Application: PCT/GB2010/050116 WO 20100126
- International Announcement: WO2010/086646 WO 20100805
- Main IPC: A61K31/4706
- IPC: A61K31/4706 ; C07D213/38 ; C07D213/34 ; C07D213/22 ; A61K31/47 ; A61K31/4433

Abstract:
Compounds of the invention are of the formula (I); wherein: is a double bond and X is C; or is a single bond and X is N, CH or CQR1; and wherein: n is 1 to 10; R is H or QR1; each R′ is independently selected from H and QR1; each Q is independently selected from a bond, CO, NH, S, SO, SO2 or O; each R1 is independently selected from C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, substituted or unsubstituted aryl or heteroaryl, acyl, C1-C10 cycloalkyl, halogen, C1-C10 alkylaryl or C1-C10 heterocycloalkyl; L is a nitrogen-containing heteroaryl; and W is a zinc-chelating residue; or a pharmaceutically acceptable salt thereof. The compounds are useful in therapy.
Public/Granted literature
- US20110305729A1 Scriptaid Isosteres and Their Use in Therapy Public/Granted day:2011-12-15
Information query
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