Invention Grant
- Patent Title: Pyridinoylpiperidines as 5-HT1F agonists
- Patent Title (中): 吡啶基哌啶作为5-HT1F激动剂
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Application No.: US13363895Application Date: 2012-02-01
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Publication No.: US08748459B2Publication Date: 2014-06-10
- Inventor: Michael Philip Cohen , Daniel Timothy Kohlman , Sidney Xi Liang , Frantz Victor , Yao-Chang Xu , Bai-Ping Ying , DeAnna Piatt Zacherl , Deyi Zhang
- Applicant: Michael Philip Cohen , Daniel Timothy Kohlman , Sidney Xi Liang , Frantz Victor , Yao-Chang Xu , Bai-Ping Ying , DeAnna Piatt Zacherl , Deyi Zhang
- Applicant Address: US IN Indianapolis
- Assignee: Eli Lilly and Company
- Current Assignee: Eli Lilly and Company
- Current Assignee Address: US IN Indianapolis
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Main IPC: A61K31/445
- IPC: A61K31/445 ; C07D401/06

Abstract:
The present invention relates to compounds of formula I: or pharmaceutically acceptable acid addition salts thereof, where; R1 is C1-C6 alkyl, substituted C1-C6 alkyl, C3-C7 cycloalkyl, substituted C3-C7 cycloalkyl, C3-C7 cycloalkyl-C1-C3 alkyl, substituted C3-C7 cycloalkyl-C1-C3 alkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle; R2 is hydrogen, C1-C3 alkyl, C3-C6 cycloalkyl-C1-C3 alkyl, or a group of formula II R3 is hydrogen or C1-C3 alkyl; R4 is hydrogen, halo, or C1-C3 alkyl; R5 is hydrogen or C1-C3 alkyl; R6 is hydrogen or C1-C6 alkyl; and n is an integer from 1 to 6 inclusively. The compounds of the present invention are useful for activating 5-HTlF receptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal. The present invention also relates to a process for the synthesis of intermediates in the synthesis of compounds of Formula I.
Public/Granted literature
- US20120329820A1 Pyridinoylpiperidines As 5-HT1F Agonists Public/Granted day:2012-12-27
Information query
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