Invention Grant
US08748464B2 Use of SIRT1 activators or inhibitors to modulate an immune response
有权
使用SIRT1激活剂或抑制剂调节免疫反应
- Patent Title: Use of SIRT1 activators or inhibitors to modulate an immune response
- Patent Title (中): 使用SIRT1激活剂或抑制剂调节免疫反应
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Application No.: US12838247Application Date: 2010-07-16
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Publication No.: US08748464B2Publication Date: 2014-06-10
- Inventor: Eric M. Verdin , Melanie Ott , Hye-Sook Kwon , Hyungwook Lim
- Applicant: Eric M. Verdin , Melanie Ott , Hye-Sook Kwon , Hyungwook Lim
- Applicant Address: US CA San Francisco
- Assignee: The J. David Gladstone Institutes
- Current Assignee: The J. David Gladstone Institutes
- Current Assignee Address: US CA San Francisco
- Agency: Bozicevic, Field & Francis LLP.
- Agent Paula A. Borden
- Main IPC: A01N43/78
- IPC: A01N43/78 ; A61K31/535
Abstract:
The present disclosure provides a method of increasing an immune response in an individual, the method involving administering to an individual in need thereof an inhibitor of SIRT1. The present disclosure provides a method of reducing an immune response, e.g., to treat chronic immune hyperactivity, the method generally involving administering to an individual in need thereof an activator of SIRT1. The present disclosure provides a method of modulating activation and differentiation of CD4+ T cells.
Public/Granted literature
- US20100330114A1 Use of SIRT1 Activators or Inhibitors to Modulate an Immune Response Public/Granted day:2010-12-30
Information query
IPC分类:
