Invention Grant
US08748493B2 Inhibitors of cathepsin S for prevention or treatment of obesity-associated disorders
失效
用于预防或治疗肥胖相关疾病的组织蛋白酶S的抑制剂
- Patent Title: Inhibitors of cathepsin S for prevention or treatment of obesity-associated disorders
- Patent Title (中): 用于预防或治疗肥胖相关疾病的组织蛋白酶S的抑制剂
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Application No.: US13202339Application Date: 2010-03-22
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Publication No.: US08748493B2Publication Date: 2014-06-10
- Inventor: Karine Clement , Michele Guerre Millo , Nadia Naour
- Applicant: Karine Clement , Michele Guerre Millo , Nadia Naour
- Applicant Address: FR Paris
- Assignee: Institut National de la Sante et de la Recherche Medicale (INSERM)
- Current Assignee: Institut National de la Sante et de la Recherche Medicale (INSERM)
- Current Assignee Address: FR Paris
- Agency: Whitham Curtis Christofferson & Cook, PC
- Priority: EP09305249 20090320; EP10305119 20100204
- International Application: PCT/EP2010/053674 WO 20100322
- International Announcement: WO2010/106187 WO 20100923
- Main IPC: A61K31/165
- IPC: A61K31/165
Abstract:
The present invention relates to methods (and pharmaceutical compositions) for treating and/or preventing for obesity associated disorders, particularly related to a deregulation of glucose homeostasis, by administrating Cathepsin S inhibitors. The invention also relates to methods for diagnosing insulin resistance and glucose tolerance by measuring Cathepsin S levels in a biological sample obtained from a subject.
Public/Granted literature
- US20110301242A1 Inhibitors of Cathepsin S for Prevention or Treatment of Obesity-Associated Disorders Public/Granted day:2011-12-08
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