Invention Grant
US08748497B2 Optimized fluorocarbon emulsions for blood substitutes and other therapeutic uses
失效
用于血液代用品和其他治疗用途的优化氟碳乳液
- Patent Title: Optimized fluorocarbon emulsions for blood substitutes and other therapeutic uses
- Patent Title (中): 用于血液代用品和其他治疗用途的优化氟碳乳液
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Application No.: US12227502Application Date: 2007-05-22
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Publication No.: US08748497B2Publication Date: 2014-06-10
- Inventor: Jeffry Weers , David Klein , Cindy Johnson
- Applicant: Jeffry Weers , David Klein , Cindy Johnson
- Applicant Address: US CA San Diego
- Assignee: Alliance Pharmaceutical Corp.
- Current Assignee: Alliance Pharmaceutical Corp.
- Current Assignee Address: US CA San Diego
- Agent Kevin S. Helmbacher
- International Application: PCT/US2007/012286 WO 20070522
- International Announcement: WO2007/139827 WO 20071206
- Main IPC: A61K31/02
- IPC: A61K31/02 ; A61P7/00

Abstract:
The present invention is directed to a stable fluorocarbon emulsion having a continuous aqueous phase and discontinuous fluorocarbon phase comprising two fluorocarbons and surprisingly demonstrates that perfluorodecyl bromide is as effective in stabilizing perfluorooctyl bromide emulsions of certain concentrations than much more highly concentrated perfluorooctyl bromide/perfluorodecyl bromide emulsions without the significant problems experienced in higher concentrated emulsions such as longer organ retention times, formation of PFDB crystals, larger emulsion particles, manufacturing problems and inability of repeat dosing inherent with higher concentrations of perfluorodecyl bromide.
Public/Granted literature
- US20100298445A1 Optimized Fluorocarbon Emulsions for Blood Substitutes and Other Therapeutic Uses Public/Granted day:2010-11-25
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