Invention Grant
US08748577B2 Conjugates of biologically active polypeptides having an increased in vivo half-life
失效
具有增加的体内半衰期的生物活性多肽的缀合物
- Patent Title: Conjugates of biologically active polypeptides having an increased in vivo half-life
- Patent Title (中): 具有增加的体内半衰期的生物活性多肽的缀合物
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Application No.: US13363278Application Date: 2012-01-31
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Publication No.: US08748577B2Publication Date: 2014-06-10
- Inventor: Marc Besman , Stewart Chipman , David Leung , Jack Singer
- Applicant: Marc Besman , Stewart Chipman , David Leung , Jack Singer
- Applicant Address: US WA Seattle
- Assignee: Cell Therapeutics, Inc.
- Current Assignee: Cell Therapeutics, Inc.
- Current Assignee Address: US WA Seattle
- Agency: Christensen O'Connor Johnson Kindness PLLC
- Main IPC: C07K14/00
- IPC: C07K14/00 ; A61K38/16 ; A61K38/14
Abstract:
Disclosed are biologically active protein conjugates that comprise a biologically active polypeptide coupled via a peptide bond to a polypeptide comprising from 2 to about 500 units of a repeating peptide motif, wherein the biologically active protein conjugate exhibits a modified plasma half-life compared to the intrinsic half-life of the unconjugated biologically active polypeptide or protein. Also disclosed are methods of making and using the conjugated proteins, as well as methods for determining whether a given conjugate exhibits a modified half life relative to the intrinsic half life of the unconjugated polypeptide.
Public/Granted literature
- US20120252717A1 CONJUGATES OF BIOLOGICALLY ACTIVE PROTEINS HAVING A MODIFIED IN VIVO HALF-LIFE Public/Granted day:2012-10-04
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