Invention Grant
- Patent Title: Process for the preparation and purification of topiramate
- Patent Title (中): 托吡酯的制备和纯化方法
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Application No.: US13512355Application Date: 2010-02-05
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Publication No.: US08748594B2Publication Date: 2014-06-10
- Inventor: Lung-Hu Wang , Chun-Teng Huang
- Applicant: Lung-Hu Wang , Chun-Teng Huang
- Applicant Address: TW Tainan
- Assignee: Scinopharm Taiwan, Ltd.
- Current Assignee: Scinopharm Taiwan, Ltd.
- Current Assignee Address: TW Tainan
- Agency: VLP Law Group LLP
- Agent Enshan Hong; Kent H. Cheng
- International Application: PCT/US2010/023353 WO 20100205
- International Announcement: WO2011/096934 WO 20110811
- Main IPC: C07H1/00
- IPC: C07H1/00 ; C07H3/00 ; C08B37/00

Abstract:
A process for the preparation of topiramate in an one pot reaction comprises the following steps: A) reacting 2,3:4,5-bis-O-{1-methylethylidene)-β-D-fructopyranose with sulfurylchloride in xylene in the presence of an organic or inorganic base to form 2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfuryl chloride, B) adding a second organic solvent to the mixture obtained in step A) C) reacting the mixture obtained in step B) with ammonia to form topiramate.
Public/Granted literature
- US20120232258A1 Process for the Preparation and Purification of Topiramate Public/Granted day:2012-09-13
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