Methods, systems, and computer readable media for automatic generation of graphic artwork to be presented by a device during playing or browsing of a media file by the device are provided. One method includes providing, via a computer or mobile device, a user interface through which a user can select a media file for which graphic artwork is to be generated and initiate automatic graphic artwork generation for the media file. The method further includes providing access to a media file graphic artwork generator via the computer or mobile device, where the media file graphic artwork generator, in response to user selection of the media file and the initiation of the media file artwork generation, automatically selects a plurality of images from at least one group of images, varies parameters of at least some of the images, and combines the images to form a graphic artwork file. At least one of the image selecting, the image parameter varying, and the image combining is performed using an algorithm structured to produce varying output in successive iterations of the algorithm invoked with the same input. The media file graphic artwork generator associates the graphic artwork file with the media file for display when the media file is browsed, displayed or played.