A frame structure for a saddle-ride type vehicle includes a body frame having a head pipe, down tubes, seat rails and upper tubes and a unit swing power unit swingably supported by the body frame. The seat rails have front ends joined to downwardly extending portions of the down tubes. The down tube has a second bending portion formed at the rear end of the horizontal extending portion and an obliquely upwardly extending portion extending rearwardly and upwardly at a position behind the second bending portion. The obliquely upwardly extending portion has a rear end joined to the seat rail. The power unit support portion is formed behind the bending portion.