A device for locking a motor vehicle opening panel, and a latch designed for such a locking device. The opening panel includes an opening mechanism so that it can be moved between a closed position in which the opening panel closes off an opening in the roof of the vehicle, and an open position in which the opening panel at least partially uncovers the opening. The opening mechanism includes at least one link rod, a first end of which is articulated to the vehicle about a first fixed transverse axis and a second end of which is articulated to the mobile opening panel about a second transverse axis. The opening panel is mounted to pivot about a third transverse axis able to move longitudinally with respect to the roof. The locking device includes a latch including a base fixed to the opening panel and including a throat configured to accept a fist striker in the closed position and a second striker in the open position. At least one of the strikers is mounted to move relative to the latch and relative to the vehicle.