A blockout device for a USB port is disclosed. The blockout device prevents contamination, damage or misuse of the USB port when not in use. The blockout device includes a locking member, a body member and a shell. The locking member has a bottom and a top. The bottom of the locking member includes a plurality of teeth for engaging the USB port. The body member has a top, a bottom and sides defining a channel therein. The locking member is positioned within the channel of the body. The shell has a cavity that receives the locking member and the body member. The locking member and the body member are positioned within the cavity of the shell when the blockout device is installed in the USB port.