A gasket member is provided for use with a fluid processing cassette having a plurality of valve stations and a fluid processing system having a valve assembly with a plurality of valve actuators. The valve stations and valve actuators are positioned in discrete locations, with the location of each valve station corresponding to the location of an associated valve actuator. The gasket member includes a filter layer and a support layer, the support layer being made of a support material. The support layer includes discrete portions of support material corresponding generally to the discrete locations of the valve stations and the valve actuators.