Invention Grant
- Patent Title: Unnatural amino acid radiolabeling precursor
- Patent Title (中): 非天然氨基酸放射性标记前体
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Application No.: US12085679Application Date: 2006-11-28
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Publication No.: US08758724B2Publication Date: 2014-06-24
- Inventor: Osamu Ito , Akio Hayashi , Fumie Kurosaki , Masahito Toyama , Toshiyuki Shinmura , Arinori Harano
- Applicant: Osamu Ito , Akio Hayashi , Fumie Kurosaki , Masahito Toyama , Toshiyuki Shinmura , Arinori Harano
- Applicant Address: JP Tokyo
- Assignee: Nihon Medi-Physics Co., Ltd.
- Current Assignee: Nihon Medi-Physics Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Fitch, Even, Tabin & Flannery LLP
- International Application: PCT/JP2006/323659 WO 20061128
- International Announcement: WO2007/063824 WO 20070607
- Main IPC: A61K51/00
- IPC: A61K51/00 ; A61M36/14

Abstract:
It is intended to provide a novel amino acid organic compound which can be used as a labeling precursor compound for radioactive halogen-labeled amino acid compounds including [18F]FACBC, and which prevents methanol from remaining in the radioactive halogen-labeled amino acid compounds produced therefrom. The novel amino acid organic compound is a compound represented by the following formula: wherein n is an integer of 0 or of 1 to 4; R1 is an ethyl, 1-propyl or isopropyl substituent; X is a halogen substituent or a group represented by —OR2; R2 is a straight-chain or branched-chain haloalkylsulfonic acid substituent with one to 10 carbon atoms, trialkylstannyl substituent with 3 to 12 carbon atoms, fluorosulfonic acid substituent or aromatic sulfonic acid substituent; and R3 is a protective group.
Public/Granted literature
- US20080281121A1 Precursor Compound of Radioactive Halogen-Labeled Organic Compound Public/Granted day:2008-11-13
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