Invention Grant
- Patent Title: Oral vaccine
- Patent Title (中): 口服疫苗
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Application No.: US12531507Application Date: 2008-03-19
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Publication No.: US08758760B2Publication Date: 2014-06-24
- Inventor: Toshiro Shirakawa , Masato Kawabata , Tetsuo Takata , Michiko Taniguchi , Asako Okamoto , Masanori Asada , Masaaki Nakatsuji
- Applicant: Toshiro Shirakawa , Masato Kawabata , Tetsuo Takata , Michiko Taniguchi , Asako Okamoto , Masanori Asada , Masaaki Nakatsuji
- Applicant Address: JP Osaka
- Assignee: Morishita Jintan Co., Ltd.
- Current Assignee: Morishita Jintan Co., Ltd.
- Current Assignee Address: JP Osaka
- Agency: Renner, Otto, Boisselle & Sklar, LLP
- Priority: JP2007-70626 20070319
- International Application: PCT/JP2008/055815 WO 20080319
- International Announcement: WO2008/114889 WO 20080925
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/38 ; C12N1/20

Abstract:
The present invention provides an oral vaccine against a bacterial infectious disease (e.g., typhoid fever, cholera, or dysentery). The oral vaccine of the present invention is a capsule formulation in which a transformed microorganism that expresses a flagellin antigen protein or that secretes a flagellin antigen protein out of the cell of the microorganism is encapsulated with an acid-resistant membrane. Examples of the microorganism include intestinal bacteria belonging to the genus Bifidobacterium, the genus Lactobacillus, the genus Lactococcus, and the like. The form of the capsule formulation may be any one of a seamless capsule formulation, a soft capsule formulation, and a hard capsule formulation.
Public/Granted literature
- US20110311617A1 ORAL VACCINE Public/Granted day:2011-12-22
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