Invention Grant
US08758766B2 Modified Streptococcus pneumoniae pneumolysin (PLY) polypeptides
有权
改良型肺炎链球菌肺炎球菌（PLY）多肽
- Patent Title: Modified Streptococcus pneumoniae pneumolysin (PLY) polypeptides
- Patent Title (中): 改良型肺炎链球菌肺炎球菌（PLY）多肽
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Application No.: US13140894Application Date: 2009-12-22
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Publication No.: US08758766B2Publication Date: 2014-06-24
- Inventor: Eliud Oloo , Raymond Oomen , Martina Ochs , Jeremy Yethon
- Applicant: Eliud Oloo , Raymond Oomen , Martina Ochs , Jeremy Yethon
- Applicant Address: NL Bilthoven
- Assignee: The Kingdom of The Netherlands, Represented by The Mininster of Health, Welfare and Sport, on Behalf of The Minster The National Institute of Public Health and The Environment
- Current Assignee: The Kingdom of The Netherlands, Represented by The Mininster of Health, Welfare and Sport, on Behalf of The Minster The National Institute of Public Health and The Environment
- Current Assignee Address: NL Bilthoven
- Agent Patrick J. Halloran; Reza Yacoob
- International Application: PCT/CA2009/001843 WO 20091222
- International Announcement: WO2010/071986 WO 20100701
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/02 ; A61K39/09 ; A61K39/38 ; C07K14/315
Abstract:
This disclosure relates to modified Streptococcus pneumonia pneumolysm (PLY) proteins which lack hemolytic activity and can be used as immunogens in an immunogenic composition or vaccine against invasive pneumococcol diseases caused by S. pneumonia. The modified pneumolysm proteins comprise ammo acid substitutions at threonine 65, glycine 293 and cysteine 428 Nucleic acids, polypeptides encoded thereby, compositions containing the same, methods for using such nucleic acids, polypeptides and compositions are also provided.
Public/Granted literature
- US20110287046A1 MODIFIED STREPTOCOCCUS PNEUMONIA PNEUMOLYSIN (PLY) POLYPEPTIDES Public/Granted day:2011-11-24
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