Invention Grant
US08759022B2 Method for selecting mevalonate synthesis modulators using cells derived from human pluripotent cells
有权
使用源自人多能细胞的细胞选择甲羟戊酸合成调节剂的方法
- Patent Title: Method for selecting mevalonate synthesis modulators using cells derived from human pluripotent cells
- Patent Title (中): 使用源自人多能细胞的细胞选择甲羟戊酸合成调节剂的方法
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Application No.: US13805547Application Date: 2011-06-20
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Publication No.: US08759022B2Publication Date: 2014-06-24
- Inventor: Christian Pinset
- Applicant: Christian Pinset
- Applicant Address: FR Evry
- Assignee: Centre d'Etude des Cellules Souches
- Current Assignee: Centre d'Etude des Cellules Souches
- Current Assignee Address: FR Evry
- Agency: Alston & Bird LLP
- Priority: EP10166631 20100621
- International Application: PCT/IB2011/052680 WO 20110620
- International Announcement: WO2011/161611 WO 20111229
- Main IPC: C12Q1/02
- IPC: C12Q1/02
Abstract:
The invention provides a method for selecting pharmaceutical compounds affecting mevalonate or cholesterol. The method having a step for putting into contact with the pharmaceutical compounds to be tested, cells of the MSC type obtained by a method for producing cells of the MSC type from human pluripotent cells or from induced stem cells, including a step for cultivating human pluripotent cells or induced stem cells in a culture medium of: 1) one or more growth factors selected from FGFs, HGF, PDGFs, EGF, herugulins and VEGFs; and 2) one or more antioxidants selected from ascorbic acid and its derivatives, vitamin E and N-acetylcysteine.
Public/Granted literature
- US20130210059A1 Method for Selecting Mevalonate Synthesis Modulators Using Cells Derived From Human Pluripotent Cells Public/Granted day:2013-08-15
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