Invention Grant
- Patent Title: Antibodies and their use in the treatment, prevention and diagnosis of a disease associated with SOD1 abnormalities
- Patent Title (中): 抗体及其用于治疗，预防和诊断与SOD1异常相关的疾病
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Application No.: US12065403Application Date: 2006-08-31
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Publication No.: US08759029B2Publication Date: 2014-06-24
- Inventor: Jean-Pierre Julien , Makoto Urushitani
- Applicant: Jean-Pierre Julien , Makoto Urushitani
- Applicant Address: CA Quebec
- Assignee: Universite Laval
- Current Assignee: Universite Laval
- Current Assignee Address: CA Quebec
- Agency: Choate, Hall & Stewart LLP
- Agent Charles E. Lyon; Robert N. Sahr
- International Application: PCT/CA2006/001444 WO 20060831
- International Announcement: WO2007/025385 WO 20070308
- Main IPC: C12N15/00
- IPC: C12N15/00 ; C07K16/00 ; C12P21/06
Abstract:
The present invention concerns an antibody which specifically binds to an abnormal superoxide dismutase 1 (SOD1), and which neutralizes its pathologic effect when administered to an animal such as a human. The antibody of the invention is a monoclonal antibody produced by hybridoma cell lines deposited with the International Depositary Authority of Canada on Aug. 29, 2006 under accession numbers ADI-290806-01, ADI-290806-02 and ADI-290806-03. The present invention also concerns the use of the antibody of the invention in the treatment, prevention and diagnosis of neurodegenerative diseases such as Amyotrophic lateral sclerosis, Parkinson and Alzheimer in an animal such as a human.
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