Invention Grant
US08759066B2 Thrombin activator compositions and methods of making and using the same
有权
凝血酶活化剂组合物及其制备和使用方法
- Patent Title: Thrombin activator compositions and methods of making and using the same
- Patent Title (中): 凝血酶活化剂组合物及其制备和使用方法
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Application No.: US12935235Application Date: 2009-04-07
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Publication No.: US08759066B2Publication Date: 2014-06-24
- Inventor: Paul D. Bishop , Tracey A. Pownder , Paul O. Sheppard , Christopher J. Stenland
- Applicant: Paul D. Bishop , Tracey A. Pownder , Paul O. Sheppard , Christopher J. Stenland
- Applicant Address: US WA Seattle
- Assignee: Zymogenetics, Inc.
- Current Assignee: Zymogenetics, Inc.
- Current Assignee Address: US WA Seattle
- Agency: Sterne, Kessler, Goldstein & Fox, PLLC
- International Application: PCT/US2009/039757 WO 20090407
- International Announcement: WO2009/126616 WO 20091015
- Main IPC: C12N9/48
- IPC: C12N9/48 ; C12N15/00 ; C12P21/06 ; C12P21/04 ; C07H21/04
Abstract:
Disclosed are compositions for activating thrombin precursors to thrombin. The compositions provided include polypeptide compositions wherein the pre-pro-sequence comprises a thrombin cleavage site. The compositions provided also include polynucleotides encoding said polypeptides and recombinant systems for expressing said polypeptides. This disclosure also relates to methods for producing said compositions, recovering said compositions, activating said compositions purifying said compositions and producing active thrombin molecules using the active form of said compositions.
Public/Granted literature
- US20110151536A1 THROMBIN ACTIVATOR COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME Public/Granted day:2011-06-23
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