A sensor for detecting an electric field fluctuation associated with the permeabilization of a bacterial cell wall comprises a substrate, at least two electrodes integrated on the substrate, an amplifier integrated on the substrate, and a processor electrically connected to the amplifier to analyze the amplified signal. The substrate and the at least two electrodes define a well between the at least two electrodes, and the at least two electrodes being configured to generate a signal in response to an electric field fluctuation in close proximity to the well or the electrodes triggered when at least one antibacterial agent associated with the well contacts a cognate target. The amplifier is configured to generate an amplified signal in response to the signal. In addition, the processor is electrically connected to the amplifier to analyze the amplified signal.