Invention Grant
US08759299B2 Analogues of insulin-like growth factor-1 (IGF-1) having amino acid substitution at position 59
有权
在59位具有氨基酸取代的胰岛素样生长因子-1（IGF-1）的类似物
- Patent Title: Analogues of insulin-like growth factor-1 (IGF-1) having amino acid substitution at position 59
- Patent Title (中): 在59位具有氨基酸取代的胰岛素样生长因子-1（IGF-1）的类似物
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Application No.: US13386220Application Date: 2010-07-22
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Publication No.: US08759299B2Publication Date: 2014-06-24
- Inventor: Zheng Xin Dong , Nicholas C. Prairie , Maria L. Ufret , Jundong Zhang , Deborah M. Rothman , Jeanne Mary Comstock
- Applicant: Zheng Xin Dong , Nicholas C. Prairie , Maria L. Ufret , Jundong Zhang , Deborah M. Rothman , Jeanne Mary Comstock
- Applicant Address: FR Paris
- Assignee: Ipsen Pharma S.A.S.
- Current Assignee: Ipsen Pharma S.A.S.
- Current Assignee Address: FR Paris
- Agent Janice M. Klunder
- International Application: PCT/US2010/002062 WO 20100722
- International Announcement: WO2011/011072 WO 20110127
- Main IPC: A61K38/16
- IPC: A61K38/16 ; A61K38/00
Abstract:
The present invention relates to novel analogues of insulin-like growth factor-1 (IGF-1), pharmaceutical compositions containing said analogues, and the use of said analogues for treatment of IGF-1-receptor mediated conditions, such as short stature, diabetes therapy, neurodegenerative disease treatment, and cartilage repair. More particularly, the present invention relates to novel analogues of IGF-1 having an amino acid substitution at position 59, e.g., (Asn59)hIGF-1(1-70)-OH (SEQ ID NO:1), and other substitution(s) as defined herein.
Public/Granted literature
- US20120190616A1 Analogues of Insulin-Like Growth Factor-1 (IGF-1) Having Amino Acid Substitution at Position 59 Public/Granted day:2012-07-26
Information query
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